Chemical examination of an unidentified sponge associated marine fungus Penicillium terrestre resulted in the isolation of eight compounds. Their structures are identified as cyclo （glycyl-D-proline） （1）, cyclo （L-prolyl-L-alanine） （2）, cyclo （L-prolyl- D-alanine） （3）, cyclo （L-leucyl-trans-4-hydroxy-L-proline） （4）, cyclo （L-leucyl-cis-4-hydroxy-D-proline） （5）, cyclo （L-trans-（4- hydroxyprolinyl）-L-phenylalanine） （6）, hexylitaconic acid （7）, and hexylitaconic methylate （8）, based on spectroscopic analysis （1D, 2D NMR）. Compounds 7, 8 were obtained from the genus Penicillium for the first time, while compounds 1-6 were isolated from the fungus Penicillium terrestre for the first time.
